Anti-?EGFR [DH8.3] | Ximbio 152934 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-?EGFR [DH8.3]

catalog :

152934

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1950

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-?EGFR [DH8.3]

Catalogue Number :

152934

Applications :

ELISA FACS IHC IP WB

Antigen/Gene or Protein Targets :

Epidermal growth factor. Truncated EGF receptor (RGFR typeIII/EGFRvIII/deltaEGFR). Recognises an EGFR with truncated extracellular domain, present on human tumours.

Synonyms :

Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, EGF R, EGFR, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Epidermal growth factor receptor, erb-b2 receptor tyrosine kinase 1, ERBB, ERBB1, Errp, HER1, mENA, NISBD2, Oncogen ERBB, PIG61, Proto-oncogene c-ErbB-1, Receptor tyrosine protein kinase ErbB 1

Reactivity :

Human

Relevance :

Epidermal growth factor receptor (EGFR) has attracted considerable attention as a target for cancer therapy. Wild-type (wt)EGFR is amplified in a number of tumor types, and several mutant forms of the coding gene have been found, with deltaEGFR, a deletion mutation lacking exons 2–7 of the external domain, being the most common and particularly associated with glioblastoma. Anti-?EGFR [DH8.3] recognises the junctional region of the truncated receptor.

Host :

Mouse

Immunogen :

Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC,conjugated to keyhole limpet haemcyanin.

Subclass :

IgG1

Myeloma Used :

NS0

Research Area :

Cancer, Cell Signaling & Signal Transduction

more info or order :

Ximbio product webpage