Anti-SOS1 [TR16-7-3] | Ximbio 152915 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-SOS1 [TR16-7-3]

catalog :

152915

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1855

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-SOS1 [TR16-7-3]

Catalogue Number :

152915

Applications :

IHC IF IP WB

Antigen/Gene or Protein Targets :

Son of sevenless homolog 1

Reactivity :

Human

Relevance :

Son of sevenless homolog 1 (SOS1) is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. SOS1 promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, SOS1 regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) and Noonan syndrome type 4 (NS4). SOS1 mutations engender a high prevalence of pulmonary valve disease and atrial septal defects.

Host :

Mouse

Myeloma Used :

Sp2/0

Research Area :

Cancer, Cardiovascular, Cell Signaling & Signal Transduction

more info or order :

Ximbio product webpage