Anti-L1CAM [RT9-20] | Ximbio 152878 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-L1CAM [RT9-20]

catalog :

152878

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RT9-20

reactivity :

human, mouse

application :

ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-L1CAM [RT9-20]

Catalogue Number :

152878

Applications :

ELISA IF

Antigen/Gene or Protein Targets :

L1 Cell adhesion molecule

Synonyms :

Antigen identified by monoclonal antibody R1, CAML1, CD171, CD171 antigen, HSAS, HSAS1, Hyd, L1, L1 cell adhesion molecule, L1-NCAM, L1cam, L1CAM_HUMAN, MASA

Reactivity :

Mouse

Relevance :

L1CAM can be detected between 200-220 kD. In brain samples it is typically seen at ~ 200 kD. When the protein is overexpressed in vitro it is often detected as a doublet with bands at 200 and 220 kD. The unglycosylated, unprocessed L1CAM is ~ 140-150 kDa. The protein has 21 putative N-glycosylation sites on the extracellular portion of the protein which, when they are all glycosylated, results in a detected MW of 200-220 kD depending upon how many residues are actually glycosylated. L1CAM can be cleaved by the metalloprotease ADAM10 resulting in fragments of 180 kD and 40 kD. L1CAM can also be cleaved by plasmin resulting in fragments of 140 kD and 80 kD. In theory, therefore, one could detect bands at ~220, 200, 180, 140, 80 and 40 kD.

Host :

Rat

Myeloma Used :

Sp2/0

Research Area :

Adhesion, Cell Signaling & Signal Transduction, Neurobiology

more info or order :

Ximbio product webpage