Anti-Phospho HDAC1 (Ser406) [BT15-59-5] | Ximbio 152876 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Phospho HDAC1 (Ser406) [BT15-59-5]

catalog :

152876

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3065

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-Phospho HDAC1 (Ser406) [BT15-59-5]

Catalogue Number :

152876

Applications :

IF IP WB

Antigen/Gene or Protein Targets :

Histone Deacetylase 1 (HDAC1)

Synonyms :

DKFZp686H12203, GON 10, HD1, HDAC 1, HDAC1, HDAC1_HUMAN, Histone deacetylase 1, Reduced potassium dependency yeast homolog like 1, RPD3, RPD3L1

Reactivity :

Human and Mouse

Relevance :

HDAC1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Host :

Mouse

Subclass :

IgG2b kappa

Myeloma Used :

Sp2/0

Research Area :

Cardiovascular, Epigenetics & Nuclear Signalling, Stem Cell Biology

more info or order :

Ximbio product webpage