Anti-ABI1/E3B1 [W8-3] | Ximbio 152864 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-ABI1/E3B1 [W8-3]

catalog :

152864

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-ABI1/E3B1 [W8-3]

Catalogue Number :

152864

Applications :

IF IP WB

Antigen/Gene or Protein Targets :

Abelson interactor 1/Eps8 binding protein 1

Reactivity :

Human and Mouse

Relevance :

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

Host :

Mouse

Subclass :

IgG1 kappa

Myeloma Used :

Sp2/0

Research Area :

Adhesion, Cancer, Cell Signaling & Signal Transduction, Gene Expression, Neurobiology

more info or order :

Ximbio product webpage