product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-LRP6 [1c10]
catalog :
152822
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4040
reactivity :
human, mouse
application :
western blot
more info or order :
Ximbio product webpage
product information
Name :
Anti-LRP6 [1c10]
Catalogue Number :
152822
Applications :
WB
Antigen/Gene or Protein Targets :
LRP6
Synonyms :
ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, Low density lipoprotein receptor related protein 6, Low-density lipoprotein receptor-related protein 6, LRP-6
Reactivity :
Human and Mouse
Relevance :
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
Host :
Mouse
Subclass :
IgG1
Research Area :
Cell Signaling & Signal Transduction, Stem Cell Biology
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com