Anti-FANCB [M38P3E10] | Ximbio 152796 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-FANCB [M38P3E10]

catalog :

152796

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2187

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-FANCB [M38P3E10]

Catalogue Number :

152796

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

Fanconi Anemia, Complementation Group B (FANCB)

Synonyms :

FA2, FAAP90, FAAP95, FAB, FACB, Fancb, FANCB_HUMAN, Fanconi anemia associated polypeptide of 95 kDa, Fanconi anemia group B protein, Fanconi anemia, complementation group B, Fanconi anemia-associated polypeptide of 95 kDa, Protein FACB

Reactivity :

Human

Relevance :

FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Host :

Mouse

Immunogen :

Ovalbumin-conjugated synthetic peptide- DRRENIHPYR

Subclass :

IgG1 kappa

Positive Control :

IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray

Molecular Weight (kDa) :

Myeloma Used :

P3X63Ag8.653

Strain :

Balb/c

Research Area :

Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling

Notes :

For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0

more info or order :

Ximbio product webpage