antibody

Anti-CIDE A [V62P1E3*B10]

152792

monoclonal

mouse

nonconjugated

1056

western blot, ELISA, immunohistochemistry

152792

ELISA IHC WB

Cell Death-Inducing DFFA-Like Effector A (CIDE A)

Cell death activator CIDE A, Cell Death Inducing DFFA Like Effector A, cell death inducing DNA fragmentation factor, alpha subunit like effector A, CIDE-A, CIDEA

Human

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICARD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B (for cell death inducing DFF like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE A is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE A is expressed in many tissues.

Mouse

Ovalbumin-conjugated synthetic peptide- QAKGRFTCG

IgG1 kappa

IHC - formalin-fixed, paraffin-embedded multi tumour tissue microarray

P3X63Ag8.653

Balb/c

Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Cell Cycle, Epigenetics & Nuclear Signalling, Metabolism, Protein Degradation

For IHC antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0