Anti-BAG3 [V65P1E8*D2] | Ximbio 152781 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-BAG3 [V65P1E8*D2]

catalog :

152781

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6545

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-BAG3 [V65P1E8*D2]

Catalogue Number :

152781

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

BAG family molecular chaperone regulator 3

Synonyms :

BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1

Reactivity :

Human

Relevance :

Anti-BCL2-Associated Athanogene 3 (BAG3) [V65P1E8*D2] is specific for human BAG3. BAG3 is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity. Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.

Host :

Mouse

Immunogen :

Ovalbumin-conjugated synthetic peptide MTDTPGNPAAP

Subclass :

IgG1 kappa

Myeloma Used :

P3X63Ag8.653

Strain :

Balb/c

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Metabolism

more info or order :

Ximbio product webpage