Anti-P15PAF [K11-P1G7*B8] | Ximbio 152728 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-P15PAF [K11-P1G7*B8]

catalog :

152728

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9768

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-P15PAF [K11-P1G7*B8]

Catalogue Number :

152728

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

PCNA-Associated Factor of 15 (PAF15)

Reactivity :

Human

Relevance :

Proliferating cell nuclear antigen (PCNA)-Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24). Under DNA damage conditions, PAF15 regulates the switch from DNA replicative polymerase to translesion synthesis polymerase in order to bypass the replication-blocking lesions. Overexpression of PAF15 promotes the repair of ultraviolet-induced DNA damage and prevents cell death, whereas attenuation of PAF15 decreases DNA replication and cell survival.

Host :

Mouse

Immunogen :

Peptide Sequence – RKACPLQPDHT -peptide immunogen is identical in mouse (Mus musculus) and rat (Rattus norvegicus).

Subclass :

IgG2b kappa

Positive Control :

ELISA - peptide immunogen; WB - Jurkat whole cell lysate; IHC - formalin-fixed, paraffin-embedded multi tumour tissue microarray

Myeloma Used :

P3X63Ag8.653

Strain :

Balb/c

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Metabolism

more info or order :

Ximbio product webpage