Anti-PALB2 [M41-P3F3] | Ximbio 152698 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-PALB2 [M41-P3F3]

catalog :

152698

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

675

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-PALB2 [M41-P3F3]

Catalogue Number :

152698

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

Partner and localizer of BRCA2

Reactivity :

Human

Relevance :

PALB2 plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.

Host :

Mouse

Immunogen :

Peptide Sequence – KENQFLMPPEE

Subclass :

IgG1 kappa

Positive Control :

IHC- formalin-fixed, paraffin-embedded multi tumour tissue microarray

Research Area :

Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage