product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-SCL [1E6]
catalog :
152650
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
30766
reactivity :
zebrafish
application :
western blot, immunocytochemistry
more info or order :
Ximbio product webpage
product information
Name :
Anti-SCL [1E6]
Catalogue Number :
152650
Applications :
IF WB
Antigen/Gene or Protein Targets :
Stem Cell Leukemia protein
Reactivity :
zebrafish
Relevance :
Zebrafish has an immune system similar to human and mutant zebrafish generate models for human disease. "Stem Cell Leukemia" (SCL) was assigned to a gene involved in a t(1;14) translocation associated with an acute leukemia with early T-cell phenotype and myeloid differentiation potential. SCL is a transcription factor of the basic helix-loophelix (bHLH) family and normally functions as a critical regulator of hematopoiesis. It is expressed in hematopoietic stem cells (HSCs), erythroid and megakaryocytic lineages but not in granulocyte/monocytes or lymphocytes. It is also expressed in the endothelium. SCL could be a major factor for the determination of hematopoietic and endothelial cell lineages. The study of SCL gene in zebrafish improves the understanding of genetic mechanisms involved in stem cell development and leukaemia generation. Most importantly, the key molecules involved in leukaemia could be identified and targeted by therapeutic drugs.
Host :
Mouse
Immunogen :
GST-SCL (N-terminal) fusion protein
Subclass :
IgG1
Myeloma Used :
Sp2/0-Ag14
Research Area :
Aquaculture, Stem Cell Biology
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com