Anti-ORF7a [3C9] | Ximbio 152647 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-ORF7a [3C9]

catalog :

152647

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3C9

application :

western blot, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-ORF7a [3C9]

Catalogue Number :

152647

Applications :

IF WB

Antigen/Gene or Protein Targets :

SARS CoV ORF7a (also known as U122)

Reactivity :

Virus

Relevance :

A novel coronavirus (termed as SARS-CoV) has been identified as the etiological agent of severe acute respiratory syndrome (SARS). The SARS-CoV genome encodes the essential CoV replication and structural proteins. In addition, the genome encodes eight 8 putative accessory proteins (i.e. ORFs 3a, 3b, 6, 7a, 7b, 8a, 8b and 9b) that do not show significant homology to viral proteins of known coronaviruses, i.e. they are unique to SARS-CoV. ORF7a, which is also known as U122, consists of 122 amino acids and is localized mainly in ER-Golgi intermediate compartment, where coronaviruses are known to assemble and bud. Interestingly, ORF7a can also be incorporated into the virion. The over-expression of ORF7a induces apoptosis and block cell cycle progression at G0/G1 phase. Another study showed that the over-expression of ORF7a inhibited cellular protein synthesis and induced the phosphorylation and activation of p38 mitogen activated protein kinase (MAPK).

Host :

Mouse

Immunogen :

GST-7a (16-111 amino acids)

Subclass :

IgG1

Molecular Weight (kDa) :

Myeloma Used :

Sp2/0-Ag14

Research Area :

Cell Signaling & Signal Transduction, Neurobiology

more info or order :

Ximbio product webpage