Anti-Cathepsin L [4C11] | Ximbio 152642 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Cathepsin L [4C11]

catalog :

152642

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1514

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

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product information

Name :

Anti-Cathepsin L [4C11]

Catalogue Number :

152642

Applications :

IF WB

Antigen/Gene or Protein Targets :

Cathepsin L, HCL

Reactivity :

Human

Relevance :

Cathepsin L is expressed in most cells but in a higher level in cancerous cells. Normal levels of cathepsin L is involved in the regulation of epithelial cell proliferation and differentiation in the skin. It is recognized that many cancer cells secrete cathepsin L to degrade the components of extracellular matrices and basement membranes. This promotes tumor invasion and metastasis. The pro-form of cathepsin L exists as a molecular size of 50kDa. The pro-form could be degraded and secreted out as two smaller forms of cathepsin L. These smaller forms are known as the mature forms. The pro-forms and mature forms are secreted out of the healthy cells. However, there is a significant increase in levels of pro-forms that are secreted out of the cancerous cells. Monoclonal antibodies generated against pro-form of cathepsin L would be useful for diagnostic purposes.

Host :

Mouse

Immunogen :

GST-HCL fusion protein

Subclass :

IgM

Positive Control :

Human brain cell lysates, U-138MG cell line

Myeloma Used :

Sp2/0-Ag14

Research Area :

Adhesion, Cancer, Cell Signaling & Signal Transduction, Neurobiology, Protein Degradation

more info or order :

Ximbio product webpage