Anti-mib [6B2] | Ximbio 152640 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-mib [6B2]

catalog :

152640

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

352910

reactivity :

zebrafish

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-mib [6B2]

Catalogue Number :

152640

Applications :

Antigen/Gene or Protein Targets :

mind bomb

Reactivity :

zebrafish

Relevance :

Zebrafish mind bomb (mib) was isolated in a large-scale screen aiming for morphologically discernible phenotypes. Mib mutants have phenotypes similar to Notch pathway mutants: a dramatic increase of primary neurons and somatic segmentation abnormalities. mib was positional cloned to be a novel gene. Mib is a novel E3 ligase with three Ring Finger (RF) domains in the C-terminal. Mib can interact with Delta, a Notch ligand. The interaction will mediate a RF-dependent ubiquitination and endocytosis of Delta, and thus effectively activates Notch in neighbouring cells. In addition, there are a series of mib alleles with different genetic severity. The most severe phenotype of antimorphic mibta52b allele is partly due to the antagonization of a second Mib homolog, Mib2, by Mibta52b protein.

Host :

Mouse

Immunogen :

GST fusion-Fish mib protein

Subclass :

IgG2b

Positive Control :

zebrafish

Myeloma Used :

Sp2/0-Ag14

Research Area :

Aquaculture

more info or order :

Ximbio product webpage