Anti-BHMT [3E7] | Ximbio 152637 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-BHMT [3E7]

catalog :

152637

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3E7

reactivity :

Dermonema virens

application :

western blot, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-BHMT [3E7]

Catalogue Number :

152637

Applications :

FACS WB

Antigen/Gene or Protein Targets :

Betaine homocysteine S-methyltransferase

Reactivity :

zebrafish

Relevance :

Betaine homocysteine S-methyltransferase (BHMT) shares 61% sequence homology between human and mouse gene. This 406 amino acids protein is found in both eukaryotes and prokaryotes. Homocysteine is generated from S-adenosylhomocysteine (SAH) through S adenosylhomocysteine hydrolase (SAHH) catalyzed reaction, into homocysteine and adenosine. This reversible reaction is thermodynamically favoured in the reverse reaction, synthesizing SAH. Therefore, to prevent the reverse reaction, adenosine is metabolized by adenosine deaminase and homocysteine is metabolized through several means of which BHMT is one of them. The action of BHMT is to catalyze resynthesis of methionine using homocysteine and methyl donor betaine. Betaine could be obtained from diet and in mammalian cells, it can be produced by choline oxidation in liver and kidney. Studies in many animal models revealed that liver and kidney are main organs for BHMT. BHMT presence is also detected in lens as well as in hepatocyte membrane, which thus lends speculations about other possible physiological roles besides methionine synthesis. Therefore, much studies have to be undertaken, to understanding the other physiological roles, if any, of BHMT besides the traditional role in methylation in future.

Host :

Mouse

Immunogen :

GST-BHMT fusion protein

Subclass :

IgG1

Positive Control :

Zebrafish embryo lysate

Myeloma Used :

Sp2/0-Ag14

Research Area :

Aquaculture, Cancer, Cell Signaling & Signal Transduction, Metabolism

more info or order :

Ximbio product webpage