Anti-BF-1 [3C6] | Ximbio 152636 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-BF-1 [3C6]

catalog :

152636

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2290

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-BF-1 [3C6]

Catalogue Number :

152636

Applications :

IF WB

Antigen/Gene or Protein Targets :

BF-1

Reactivity :

Human

Relevance :

Apoptosis in host cells during infection is thought to serve as a defense mechanism for the removal of the infectious agents. Pathogenic bacteria could be broadly classified as invasive or non-invasive. Certain invasive pathogens have been reported to inhibit apoptosis in the host cells so as to persist, multiply and avoid components of the circulating immune system. Mechanistic analysis of this process not only would help to understand the infectious process, but it would certainly provide important clues to help understand the composition of the fundamental machineries and mechanisms of the apoptosis regulation in mammalian cells. In this regard, studies have been focusing on the identification of the bacterial factor(s) that might be involved in the inhibition of apoptosis signaling of host cells during infection. One factor identified, termed BF-1, appear to be capable of inhibiting apoptosis in infected epithelial cells. Furthermore, mammalian epithelial cells expressing this factor were rendered resistant to apoptosis mediated by several apoptotic stimuli (unpublished data).

Host :

Mouse

Immunogen :

GST-BF-1 fusion protein

Subclass :

IgG1

Myeloma Used :

Sp2/0-Ag14

Research Area :

Apoptosis and Programmed Cell Death, Bacteriology, Cell Signaling & Signal Transduction

more info or order :

Ximbio product webpage