product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-Beta3 [7D1]
catalog :
152635
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1629
reactivity :
human
application :
western blot, immunocytochemistry, FACS
more info or order :
Ximbio product webpage
product information
Name :
Anti-Beta3 [7D1]
Catalogue Number :
152635
Applications :
FACS IF WB
Antigen/Gene or Protein Targets :
Beta3 subunit of high-voltage-gated calcium channel
Reactivity :
Human
Relevance :
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omegaagatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3. The beta3 (?3) subunit of high-voltage-gated calcium channels is a peripheral membrane protein that co-purifies with neural N-type calcium channels. Beta3 subunit contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
Host :
Mouse
Immunogen :
GST-beta3 fusion protein
Subclass :
IgG1
Myeloma Used :
Sp2/0-Ag14
Research Area :
Epigenetics & Nuclear Signalling, Neurobiology
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com