Anti-Bam32 [4H9] | Ximbio 152634 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Bam32 [4H9]

catalog :

152634

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2887

reactivity :

human

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-Bam32 [4H9]

Catalogue Number :

152634

Applications :

Antigen/Gene or Protein Targets :

B lymphocyte-associated adaptor protein

Reactivity :

Human

Relevance :

B lymphocyte-associated adaptor protein (Bam32) is 32 kDa and is expressed in high levels in the germinal center (GC) of B cells. It consists of a src homology 2 (SH2) domain at the NH2 terminal which binds phospholipase C (PLC) gamma 2 and a pleckstrin homology (PH) domain at the COOH-terminal. Bam32 acts as an adaptor that integrates protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K) necessary for signaling in B cells. Bam32 is recruited to the plasma membrane upon B cell receptor (BCR) ligation. BCR ligation induces colocalization of Bam32 with lipid rafts, clathrin, and actin filaments. BCR internalization which is actin dependent occurs subsequently. Bam32 also play a part in B cell proliferation.

Host :

Mouse

Immunogen :

GST-Bam32 fusion protein

Subclass :

IgG1

Positive Control :

A20 cell lysate

Myeloma Used :

Sp2/0-Ag14

Research Area :

Cell Signaling & Signal Transduction, Immunology

more info or order :

Ximbio product webpage