Anti-EBV Latent Membrane Protein 1 [LMPO24] | Ximbio 152632 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-EBV Latent Membrane Protein 1 [LMPO24]

catalog :

152632

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LMPO24

application :

immunohistochemistry, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-EBV Latent Membrane Protein 1 [LMPO24]

Catalogue Number :

152632

Applications :

FACS IHC

Antigen/Gene or Protein Targets :

Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)

Reactivity :

Virus

Relevance :

EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.

Host :

Mouse

Immunogen :

Purified plasma membranes from LMP1 expressing insect cells infected with a recombinant LMP1 baculovirus

Subclass :

IgG1

Positive Control :

EBV transformed lymphoblastoid cell lines

Strain :

Balb/c

Research Area :

Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Virology

Notes :

Niedobitek et al., 1995: "The LMPO24 clone demonstrates strong and specific reactivity in immunohistochemical staining of paraffin-embedded tissues".

more info or order :

Ximbio product webpage