Anti-p53 [V5P4H6*B3] | Ximbio 152613 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-p53 [V5P4H6*B3]

catalog :

152613

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

30590

reactivity :

zebrafish

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-p53 [V5P4H6*B3]

Catalogue Number :

152613

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

p53

Reactivity :

zebrafish

Relevance :

p53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Host :

Mouse

Immunogen :

Ovalbumin-conjugated synthetic peptide KLMVKDEGRS (C-terminal sequence)

Subclass :

IgG1 kappa

Positive Control :

WB - whole Zebrafish lysate; IHC- Zebrafish embryo

Research Area :

Aquaculture, Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage