Anti-sCTLA4 [L4P2F5*F10] | Ximbio 152604 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-sCTLA4 [L4P2F5*F10]

catalog :

152604

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

22839

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-sCTLA4 [L4P2F5*F10]

Catalogue Number :

152604

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

Cytotoxic T-lymphocyte-associated protein 4, sCTLA4 molecule (sCTLA4 soluble form)

Synonyms :

Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; CTLA-4; CD152; CD152 Antigen; CELIAC3; IDDM12; ALPS5; GRD4; GSE; CD

Reactivity :

Bovine, Human, Mouse and Rat

Relevance :

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others. There is strong evidence showing variation of sCTLA4 levels between individuals ranging from approximately 150 to around 10,000 pg/ ml. One can speculate that those patients with high sCTLA4 levels are unlikely to benefit from CTLA4 therapy. Hence, it is crucial to measure/ quantify sCTLA4 before administering treatment. This anti-sCTLA4 antibody could prove a useful predictive biomarker.

Host :

Mouse

Immunogen :

Ovalbumin-conjugated synthetic peptide CENAPNRARM

Subclass :

IgG1 kappa

Positive Control :

IHC- formalin-fixed, paraffin-embedded multi tumour tissue microarray; WB - Jurkat cell lysates

Research Area :

Immunology, Stem Cell Biology

Notes :

Immunogen sequence is identical to mouse (Mus musculus), rat (Rattus norvegicus) and bovine (Bos taurus).

more info or order :

Ximbio product webpage