Anti-ERO1-Like Beta [M37-P5D11] | Ximbio 152603 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-ERO1-Like Beta [M37-P5D11]

catalog :

152603

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

56605

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-ERO1-Like Beta [M37-P5D11]

Catalogue Number :

152603

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

ERO1-Like Beta (ERO1LB)

Reactivity :

Human

Relevance :

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.

Host :

Mouse

Immunogen :

Peptide – LAPSRGEDDG

Subclass :

IgG1 kappa

Positive Control :

WB - Jurkat whole cell lysate, IHC - formalin-fixed, paraffin-embedded human breast cancer

Research Area :

Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

more info or order :

Ximbio product webpage