Anti-Cytochrome P450 46A1 [N8-P6E4*H8] | Ximbio 152600 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Cytochrome P450 46A1 [N8-P6E4*H8]

catalog :

152600

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1577

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

more info or order :

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product information

Name :

Anti-Cytochrome P450 46A1 [N8-P6E4*H8]

Catalogue Number :

152600

Applications :

ELISA IHC WB

Antigen/Gene or Protein Targets :

Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1)

Reactivity :

Human

Relevance :

Cytochrome P450 46A1 belongs to the cytochrome P450 family which are a group of monooxygenases. Cytochrome P450 46A1 is involved in the turnover of cholesterol converting it into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. This protein is expressed in the brain and mRNA has been found to be broadly distributed with higher levels in the gray matter zones and lower levels in white matter areas. It is not detected in fetal brain but its expression increases linearly with age. It localises to the endoplasmic reticulum membrane and the microsome membrane. The unprocessed precursor is 500 amino acids long and has a predicted molecular weight of 56.8KD.

Host :

Mouse

Immunogen :

Ovalbumin-conjugated synthetic peptide- PVLCTLRPR (C-terminal sequence)

Subclass :

IgG1

Positive Control :

WB - overexpression lysates

Molecular Weight (kDa) :

Research Area :

Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

Notes :

This antibody was applied in a poster presented at the 2015 NCRI conference: http://abstracts.ncri.org.uk/?s=oxysterol&year_published=2015

more info or order :

Ximbio product webpage