Anti-CD49e [SNAKA51] | Ximbio 152487 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CD49e [SNAKA51]

catalog :

152487

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3678

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

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product information

Name :

Anti-CD49e [SNAKA51]

Catalogue Number :

152487

Applications :

IF Fn WB

Antigen/Gene or Protein Targets :

Integrin alpha5 (CD49e)

Synonyms :

Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A

Reactivity :

Human

Relevance :

CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Host :

Mouse

Immunogen :

Whole cells corresponding to human Integrin alpha5.

Subclass :

IgG2a kappa

Positive Control :

HeLa cells

Myeloma Used :

P3X63Ag8.653

Research Area :

Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology

Notes :

Activity Assay: A representative lot of this antibody converts alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding. Immunocytochemistry Analysis: A representative lot of this antibody detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF)

more info or order :

Ximbio product webpage