Anti-CD49e [SNAKA52] | Ximbio 152486 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CD49e [SNAKA52]

catalog :

152486

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3678

reactivity :

human

application :

ELISA

more info or order :

Ximbio product webpage

product information

Name :

Anti-CD49e [SNAKA52]

Catalogue Number :

152486

Applications :

ELISA Fn

Antigen/Gene or Protein Targets :

Integrin alpha5 (CD49e)

Synonyms :

Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A

Reactivity :

Human

Relevance :

CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Host :

Mouse

Immunogen :

?5?1 purified from human placenta.

Subclass :

IgG

Positive Control :

HeLa cells

Myeloma Used :

P3X63Ag8.653

Research Area :

Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology

Notes :

The binding of SNAKA52 is inhibited by anti-beta1 mAbs, indicating that its epitope is close to the interface between the alpha and beta subunits.

more info or order :

Ximbio product webpage