Anti-CD49b [31H4] | Ximbio 152485 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CD49b [31H4]

catalog :

152485

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3673

reactivity :

human

application :

ELISA, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-CD49b [31H4]

Catalogue Number :

152485

Applications :

ELISA FACS IP

Antigen/Gene or Protein Targets :

Integrin alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Synonyms :

Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor; Alpha-2 Subunit; Human Platelet Alloantigen System; Platelet Glycoprotein GPIa; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR

Reactivity :

Human

Relevance :

CD49b also known as integrin alpha-2, VLA-2 subunit alpha or collogen receptor. CD49b is a 1181 amino acid ¦130 kDa single pass type-1 transmembrane glycoprotein which forms a heterodimer with integrin beta-1 and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia.

Host :

Mouse

Immunogen :

Purified human b1 integrin preparation from HT1080 fibrosarcoma cell extract.

Subclass :

IgG1

Myeloma Used :

P3X63Ag8.653

Research Area :

Adhesion, Cell Signaling & Signal Transduction, Immunology

Notes :

Does not cross-react with Rat. Mouse anti Human CD49b antibody, clone 31H4 has been identified as being capable of immunoprecipitating the integrin a2 subunit from human cell-lines surface labelled with 125I. It has been confirmed specific to a2 by relative expression of antigen on various cell lines by flow cytometry, and recognition of affinity purified a2b1 in dot blots.

more info or order :

Ximbio product webpage