Anti-Notch-1 [22E5.5] | Ximbio 152382 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Notch-1 [22E5.5]

catalog :

152382

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

22E5.5

application :

immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Notch-1 [22E5.5]

Catalogue Number :

152382

Applications :

FACS IP

Antigen/Gene or Protein Targets :

Notch-1

Synonyms :

Notch 1; Translocation-Associated Notch Protein TAN-1; TAN1; HN1; Notch (Drosophila) Homolog 1 (Translocation-Associated); AOVD1; AOS5

Relevance :

Notch1, also known as neurogenic locus notch homolog protein 1, is a large >270 kD protein that functions as a receptor for the membrane ligands Jagged1, Jagged2 and Delta1 to regulate cell fate decisions. Upon ligand activation, the transmembrane Notch1 receptor is cleaved by TNF-alpha converting enzyme (TACE) to produce a membrane-associated intermediate fragment (NEXT). This fragment is further cleaved by presenilin-dependent gamma secretase to release a notch-derived peptide containing the intracellular fragment from the membrane. The released Notch intracellular fragment (NICD) translocates to the nucleus and forms a transcriptional complex with the RBP-J ? transcriptional activator complex to alter differentiation, proliferation, and apoptotic programs. Notch 1 is highly expressed in the brain, lung, and thymus (CD4-CD8-cells and CD4-CD8+ cells) with lower levels of expression observed in the spleen, bone marrow, spinal cord, eyes, mammary gland, liver, intestine, kidney and heart.

Host :

Rat

Research Area :

Cardiovascular, Developmental Biology, Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology

more info or order :

Ximbio product webpage