product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-mIL-17A [MM17F3]
catalog :
152380
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MM17F3
application :
ELISA
more info or order :
product information
Name :
Anti-mIL-17A [MM17F3]
Catalogue Number :
152380
Applications :
ELISA Fn
Antigen/Gene or Protein Targets :
mIL-17A
Synonyms :
Interleukin 17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL-17A; CTLA8; IL17
Reactivity :
Virus
Relevance :
IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-?B and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
Host :
Mouse
Subclass :
IgG1
Research Area :
Virology
more info or order :
company information
Ximbio
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