Anti-IL-17F [9D3.1C8] | Ximbio 152374 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-IL-17F [9D3.1C8]

catalog :

152374

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

257630

reactivity :

mouse

more info or order :

Ximbio product webpage

product information

Name :

Anti-IL-17F [9D3.1C8]

Catalogue Number :

152374

Antigen/Gene or Protein Targets :

IL-17F

Reactivity :

Mouse

Relevance :

Interleukin 17F (IL-17F) is a 37 kD IL-17 family member. The IL-17 family consists of six members including IL-17 (also called IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17F shares the strongest similarity to IL-17A and forms a homodimer or heterodimer with IL-17A. It is produced by Th17 cells, mast cells, basophils, and epithelial cells. IL-17F is an important regulator of inflammatory responses. It is involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. Overexpression of the IL-17F gene in the airways of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. IL-17F is also involved in cancer immunity and autoimmune responses. IL-17F, like IL-17A, depends on IL-17R for its signaling in vitro and in vivo. P38 MAPK, ERK1/2, Act1 (NF-kB activator protein 1), and TRAF6 are involved in IL-17F signaling.

Host :

Mouse

Subclass :

IgG1

Research Area :

Cancer, Cardiovascular, Immunology

more info or order :

Ximbio product webpage