Anti-iASPP [49.3] | Ximbio 152362 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-iASPP [49.3]

catalog :

152362

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10848

reactivity :

human

application :

immunocytochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-iASPP [49.3]

Catalogue Number :

152362

Applications :

FACS IF IP

Antigen/Gene or Protein Targets :

iASPP

Reactivity :

Human

Relevance :

The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1). So far, the best-known function of the ASPP family members is their ability to regulate the apoptotic function of p53 and its family members, p63 and p73. Biochemical and genetic evidence has shown that ASPP1 and ASPP2 activate, whereas iASPP inhibits, the apoptotic but not the cell-cycle arrest function of p53.

Host :

Mouse

Immunogen :

C-terminal His-tagged fusion protein containing amino acids 459-639 of iASPP

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage