product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-CyclinD1 [LX014]
catalog :
152356
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
909
reactivity :
human
application :
western blot
more info or order :
Ximbio product webpage
product information
Name :
Anti-CyclinD1 [LX014]
Catalogue Number :
152356
Applications :
WB
Antigen/Gene or Protein Targets :
CD1
Synonyms :
CCND1; B-Cell Lymphoma 1 Protein; B-Cell CLL/Lymphoma; BCL-1 Oncogene; PRAD1; G1/S-Specific Cyclin D1; D11S287E; U21B31
Reactivity :
Human
Relevance :
The family of D-type cyclins (D1, D2, and D3) regulates the G1/S-phase transition. D cyclins bind and activate cyclin-dependent kinases (Cdk4 and Cdk6) to phosphorylate the retinoblastoma (pRb) protein, and through titration of the Cdk inhibitors p21Cip1 and p27Kip1, the cyclin D–Cdk4/6 complexes activate cyclin E/Cdk2. Genetic analysis studies in mice have demonstrated an essential role for cyclin D1 in normal development of the retina, components of the nervous system, and terminal alveolar breast bud development.
Host :
Mouse
Research Area :
Cancer, Cell Cycle, Epigenetics & Nuclear Signalling, Neurobiology
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com