Anti-Rxra [4RX-3A2] | Ximbio 152284 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Rxra [4RX-3A2]

catalog :

152284

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9213

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-Rxra [4RX-3A2]

Catalogue Number :

152284

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

RXR alpha (Retinoid X receptor alpha)

Reactivity :

Human

Relevance :

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Host :

Mouse

Immunogen :

Recomb prot

Subclass :

IgG1 kappa

Research Area :

Epigenetics & Nuclear Signalling

Notes :

Available in 100ul unit

more info or order :

Ximbio product webpage