Anti-RARA [9?-9A6] | Ximbio 152269 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-RARA [9?-9A6]

catalog :

152269

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5914

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-RARA [9?-9A6]

Catalogue Number :

152269

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

RAR Alpha

Reactivity :

Human and Mouse

Relevance :

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis.

Host :

Mouse

Immunogen :

Recombinant protein (420-443)

Research Area :

Epigenetics & Nuclear Signalling

Notes :

Available in 100ul unit No cross reactivity with RAR? and RAR?

more info or order :

Ximbio product webpage