Anti-NPM1 [4TOU-1B2] | Ximbio 152259 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-NPM1 [4TOU-1B2]

catalog :

152259

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4869

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-NPM1 [4TOU-1B2]

Catalogue Number :

152259

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

Nucleophosmin

Reactivity :

Human

Relevance :

Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Nucleophosmin stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.

Host :

Mouse

Immunogen :

Unknown

Subclass :

IgG1 kappa

Research Area :

Epigenetics & Nuclear Signalling

Notes :

Available in 100ul unit

more info or order :

Ximbio product webpage