Anti-Nsd1 [1NW-1A10] | Ximbio 152258 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Nsd1 [1NW-1A10]

catalog :

152258

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

18193

reactivity :

mouse

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-Nsd1 [1NW-1A10]

Catalogue Number :

152258

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

NSD1 (Sotos Syndrome)

Reactivity :

Mouse

Relevance :

KMT3B / NSD1 is a histone methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Defects in NSD1 are the cause of Sotos syndrome (SOTOSS) [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.

Host :

Mouse

Immunogen :

Recomb prot (738-891)

Subclass :

IgG1 kappa

Research Area :

Epigenetics & Nuclear Signalling

Notes :

Epitope localized between aa 738 and 891 Available in 100ul unit

more info or order :

Ximbio product webpage