Anti-SGG [7G-1F2] | Ximbio 152215 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-SGG [7G-1F2]

catalog :

152215

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7G-1F2

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-SGG [7G-1F2]

Catalogue Number :

152215

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

GSK-3 (SGG)

Relevance :

The Monoclonal Anti-GSK-3 / Shaggy protein kinase family, Clone 7G-1F2 reacts with both the phosphorylated peptide and the non phosphorylated peptide and with the corresponding GSK-3/Shaggy proteins. The phosphorylated peptide used as an immunogen derives from the N-terminal of the shaggy polypeptide and is well conserved in comparable regions of the rat GSK-3- alpha and beta enzymes (position 8 is a T in GSK-3-beta, and position 5 is an A in GSK-3-alpha). The reactivity with this antibody is unchanged by insulin or EGF treatments of cells and can be used as a reference when detecting changes in phosphorylation on ser9 using clone 7G-2G5. Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. Phosphorylation of a protein by GSK-3 usually inhibits the activity of its downstream target. GSK-3 is active in a number of central intracellular signaling pathways, including cellular proliferation, migration, glucose regulation, and apoptosis.

Host :

Mouse

Immunogen :

Phosphorylated synthetic peptide coupled to ovalbumine : (C)SGRPRTSSFAE

Subclass :

IgG1 kappa

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

Notes :

Available in 100ul unit as ascites. Recommended dilutions : 1/500 - 1/5000

more info or order :

Ximbio product webpage