product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-SGG [4G-1E]
catalog :
152214
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G-1E
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
more info or order :
Ximbio product webpage
product information
Name :
Anti-SGG [4G-1E]
Catalogue Number :
152214
Applications :
ELISA IHC IF WB
Antigen/Gene or Protein Targets :
GSK-3  (SGG)
Relevance :
The Monoclonal Anti-GSK-3 / Shaggy protein kinase family, clone 4G-1E, was produced using a peptide that derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Because of the extremely high conservation of this region among the known enzymes of many different species clone 4G-1E, which recognizes the Drosophila enzyme, should cross react with all species homologues (cross-reacts effectively with rat, Sch. Pombe, Dictyostelium*). Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. Phosphorylation of a protein by GSK-3 usually inhibits the activity of its downstream target. GSK-3 is active in a number of central intracellular signaling pathways, including cellular proliferation, migration, glucose regulation, and apoptosis.
Host :
Mouse
Immunogen :
Synthetic peptide coupled to ovalbumin : (C)K 203 QLLHGEPNVSYICSRY219.
Subclass :
IgG1 kappa
Research Area :
Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism
Notes :
Available in 100ul unit as ascites. Recommended dilutions : 1/1000-1/5000
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com