product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-FMRP [1C3-1a]
catalog :
152202
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2332
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
more info or order :
Ximbio product webpage
product information
Name :
Anti-FMRP [1C3-1a]
Catalogue Number :
152202
Applications :
ELISA IHC IF WB
Antigen/Gene or Protein Targets :
FMRP (Fragile X retardation protein)
Reactivity :
Human and Mouse
Relevance :
The monoclonal anti?FMRP (Fragile X Mental Retardation Protein), clone 1C3?1a recognises human and mouse FMRP. The epitope is localised in the N?terminal half of FMRP. Cross?reaction with FXR proteins may be detected in case of high expression of these proteins. FMRP, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. Mutations of this gene can lead to fragile X syndrome, mental retardation, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits. The FMR1 gene is located on the X chromosome and contains a DNA segment called CGG trinucleotide. In most people, the CGG segment is repeated in the gene approximately 5-44 times. Increased expression of the CGG segment on the FMR1 gene is associated with impaired cognitive and reproductive function.
Host :
Mouse
Immunogen :
Fusion protein with full length FMRP (human).
Subclass :
IgG1 kappa
Research Area :
Cell Cycle, Epigenetics & Nuclear Signalling, Neurobiology
Notes :
Available in 100ul unit as ascites. Applications : - ELISA - Western Blot (natural and recombinant proteins) - Immunohistochemistry (frozen and paraffin sections) - Immunocytochemistry (on transfected cells or not) - Detection of FMRP on blood smears - Immunoprecipitation : weak Recommended dilutions : 1/500 ? 1/5000
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com