Anti-ETS1 [1ET 7F2] | Ximbio 152200 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-ETS1 [1ET 7F2]

catalog :

152200

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2113

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-ETS1 [1ET 7F2]

Catalogue Number :

152200

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

ETS1 (DBD)

Reactivity :

Human and Mouse

Relevance :

The Monoclonal Anti ETS?1 (DNA Binding Domain), clone 1ET 7F2 recognises human and mouse ETS?1. It has been validated for ELISA, Western blot and Immunofluorescence. ETS1 belongs to the ETS family of transcription factors. Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells, whereas knocking Ets1 down causes multiple defects in the immune system. Meta-analyses of multiple genome-wide association studies has suggested an association of SNPs in the ETS1 locus with psoriasis in European populations. This is not surprising because Ets1 is a negative regulator of Th17 cells. Ets1 overexpression in stratified squamous epithelial cells causes pro-oncogenic changes, such as suspension of terminal differentiation, high secretion of matrix metalloproteases (Mmps), epidermal growth factor ligands, and inflammatory mediators.

Host :

Mouse

Immunogen :

(C)DEVARRWGKRKNKPK (synthetic peptide corresponding to aa 368?382 of the human ETS?1)

Subclass :

IgG1 kappa

Research Area :

Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Immunology

Notes :

Available in 100ul unit as ascites. Recommended dilutions: 1/500?1/5000

more info or order :

Ximbio product webpage