Anti-ATXN3 [2SCA-1H9] | Ximbio 152172 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-ATXN3 [2SCA-1H9]

catalog :

152172

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4287

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-ATXN3 [2SCA-1H9]

Catalogue Number :

152172

Applications :

IHC IF WB

Antigen/Gene or Protein Targets :

Ataxin3

Reactivity :

Human, Mouse and Rat

Relevance :

The Anti-Ataxin3 antibody, clone 2SCA-1H9 can be used to study wild type ataxin-3 and the mutant form with polyglutamine expansion found in patients affected with spinocerebellar ataxin type 3/Machado-Joseph disease (SCA3/MJD). In analysis of human tissues by western blot, 1H9 antibody revealed several isoforms of ataxin-3 (presumably generated by alternative splicing, Trottier et al. 1998). 1H9 antibody detected polyglutamine aggregate (or nuclear inclusions) by IHC on SCA-3/MJD brain sections (Paulson et al.1997).

Host :

Mouse

Immunogen :

Recombinant protein (112-249)

Subclass :

IgG1 kappa

Research Area :

Epigenetics & Nuclear Signalling, Neurobiology

Notes :

Available in 100ul unit as ascites. Specificity for human, monkey, rat and mouse ataxin-3 isoforms. The epitope was mapped precisely at E214-L233.

more info or order :

Ximbio product webpage