Anti-c-Met [12.1] | Ximbio 152153 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-c-Met [12.1]

catalog :

152153

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4233

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-c-Met [12.1]

Catalogue Number :

152153

Applications :

IF IP WB

Antigen/Gene or Protein Targets :

c-Met, cMet

Reactivity :

Human

Relevance :

c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.

Host :

Mouse

Immunogen :

Bacterially expressed human c-Met alpha chain

Subclass :

IgG1 kappa

Positive Control :

SNU-5, U-87MG and MKN45 cells (negative control: T47D cells)

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

DMEM containing 10% FCS

Strain :

Balb/c

Research Area :

Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

Notes :

This clone is also referred to as 5E7/G7. Clone 12.1 recognises a denatured epitope. The amino acid sequence of this epitope being: LEHPDCFPCQDCSSK Does not work in FACS

more info or order :

Ximbio product webpage