Anti-Nitrosylated Amyloid-ß (Tyr10) [4A5E8] | Ximbio 152131 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Nitrosylated Amyloid-ß (Tyr10) [4A5E8]

catalog :

152131

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

334

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-Nitrosylated Amyloid-ß (Tyr10) [4A5E8]

Catalogue Number :

152131

Applications :

ELISA IHC IP WB

Antigen/Gene or Protein Targets :

Amyloid-ß

Reactivity :

Human

Relevance :

Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the inducible nitric oxide synthase (NOS2) resulting in increased NO production. NO contributes to cell signaling by inducing posttranslational protein modifications. Under pathological conditions there is a shift from the signal transducing actions to the formation of protein tyrosine nitration by secondary products like peroxynitrite and nitrogen dioxide. Amyloid ? (A?) has been identified as an NO target, which is nitrated at tyrosine 10 (3NTyr10-A?). Nitration of A? accelerated its aggregation and was detected in the core of A? plaques of APP/PS1 mice and AD brains.

Host :

Mouse

Immunogen :

Nitration-site in Amyloid-ß nitrated at Tyrosine 10.

Research Area :

Neurobiology

more info or order :

Ximbio product webpage