Anti-Nesprin-2 [K20-478] | Ximbio 152127 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Nesprin-2 [K20-478]

catalog :

152127

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

23224

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Nesprin-2 [K20-478]

Catalogue Number :

152127

Applications :

EM ELISA FACS IHC IP WB

Antigen/Gene or Protein Targets :

Nesprin-2 (NUANCE: NUcleus ans ActiN Connecting Element)

Reactivity :

Human

Relevance :

Giant isoforms, encoded by Nesprin-1 (Syne1) and Nesprin-2 (Syne2), are multifunctional actin-binding and nuclear-envelope-associated proteins belonging to the spectrin superfamily. Nesprins play pivotal roles in maintenance of nuclear envelope integrity, nuclear positioning, and anchorage to the cytoskeleton and the centrosome. Although compelling evidence underlines nesprin's roles in several human diseases that range from cerebellar ataxia to dystrophy-like phenotypes; the underlying molecular mechanisms remain elusive.

Host :

Mouse

Immunogen :

Residues 1-459 of Nesprin-2

Research Area :

Cell Type or Organelle Marker, Cell Signaling & Signal Transduction

Notes :

Disease associations: Laminopathies, nucleoenvelopathies and nuclear biology

more info or order :

Ximbio product webpage