Anti-Cytochrome P450 26B1 [T5P3G2*A3] | Ximbio 152120 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Cytochrome P450 26B1 [T5P3G2*A3]

catalog :

152120

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1577

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

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product information

Name :

Anti-Cytochrome P450 26B1 [T5P3G2*A3]

Catalogue Number :

152120

Applications :

IHC WB

Antigen/Gene or Protein Targets :

Cytochrome P450, family 2, subfamily A, polypeptide 6, CYP26B1

Reactivity :

Human, Mouse and Rat

Relevance :

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.

Host :

Mouse

Immunogen :

Ovalbumin-conjugated synthetic peptide DSNQNEILPE (C-terminal sequence)

Subclass :

IgG1 kappa

Positive Control :

IHC: formalin-fixed, paraffin-embedded colon carcinoma sections. western blot: overexpression lysates.

Myeloma Used :

P3X63Ag8.653

Recommended Growing Conditions :

Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM plus 60 ml Fetal Bovine Serum plus 3ml L-Glutamine).

Strain :

Balb/c

Research Area :

Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

more info or order :

Ximbio product webpage