antibody

Anti-Cytochrome P450 7B1 [M17-P3F2]

152117

monoclonal

mouse

nonconjugated

1577

western blot, ELISA, immunohistochemistry

152117

ELISA IHC WB

Cytochrome P450, family 7, subfamily B, polypeptide 1 (CYP7B1)

Human

Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.

Mouse

Ovalbumin-conjugated synthetic peptide IQYPDSDVL (C-terminal sequence)

IgG1 lambda

IHC: formalin-fixed, paraffin-embedded human liver sections WB: pooled human liver microsomes

P3X63Ag8.653

Balb/c

Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism, Neurobiology

This antibody was applied in a poster presented at the 2015 NCRI conference: http://abstracts.ncri.org.uk/?s=oxysterol&year_published=2015