Anti-SMN2 [SMN-KH] | Ximbio 151940 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-SMN2 [SMN-KH]

catalog :

151940

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6606

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-SMN2 [SMN-KH]

Catalogue Number :

151940

Applications :

IHC WB

Antigen/Gene or Protein Targets :

SMN2

Reactivity :

Human

Relevance :

Survival motor neuron (SMN) protein is expressed from two linked paralogous genes: Survival of motor neuron 1, telomeric (SMN1) and Survival of motor neuron 2, centromeric (SMN2). SMNs are primarily localized in the cytoplasm and nuclear gems of all cells, where they are understood to mediate the assembly of spliceosomal small nuclear ribonucleoprotein particles (snRNPs). The progressive loss of functional SMNs in the anterior horn of the spinal cord is a critical cause of Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disease. There are three known types of childhood-onset SMA, in addition to a fourth type that is characterized by adult-onset SMA.

Host :

Mouse

Immunogen :

MBP-tagged recombinant protein corresponding to human SMN2

Subclass :

IgG1 kappa

Research Area :

Epigenetics & Nuclear Signalling, Neurobiology

more info or order :

Ximbio product webpage