Anti-CLEC2 [AYP2] | Ximbio 151914 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CLEC2 [AYP2]

catalog :

151914

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2840

reactivity :

human

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-CLEC2 [AYP2]

Catalogue Number :

151914

Applications :

Antigen/Gene or Protein Targets :

C-type lectin-like receptor 2, CLEC1b

Reactivity :

Human papilloma virus

Relevance :

Patients with rheumatoid arthritis, an inflammatory disease associated with increased microparticle production, have raised plasma levels of microparticles that expressed CLEC-2 but not GPVI. CLEC-2 can be used to monitor platelet-derived microparticles. The observation that microparticles derived from activated platelets retain CLEC-2 but lose GPVI highlights the potential use of measurement of surface expression of platelet receptors to screen for platelet activation in a wide variety of cardiovascular and inflammatory diseases.

Host :

Mouse

Immunogen :

A recombinant extracellular fragment of human CLEC-2 (aa 68-229), which is the extracellular domain of the protein.

Subclass :

IgG1

Positive Control :

Platelets

Molecular Weight (kDa) :

Myeloma Used :

Sp2/0-Ag14

Recommended Growing Conditions :

Hybridomas were cultured at 37º C and 96% relative humidity in air containing 6% CO2. Cells were grown in complete DMEM + Pen/strep + FCS was used at 10%. Cell density: Cells should be kept between 1-2x105 cells/ml and 5x105 cells/ml.

Research Area :

Cardiovascular, Immunology

Notes :

Molecular Weight- Western blotting: 32 and 40 kDa doublet from lysates as CLEC-2 is glycosylated.

more info or order :

Ximbio product webpage