Anti-FANCM [M40-P2C6] | Ximbio 151876 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-FANCM [M40-P2C6]

catalog :

151876

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

57697

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-FANCM [M40-P2C6]

Catalogue Number :

151876

Applications :

ELISA IF WB

Antigen/Gene or Protein Targets :

Fanconi Anemia, Complementation Group M (FANC-M)

Synonyms :

Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250

Reactivity :

Human

Relevance :

Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.

Host :

Mouse

Immunogen :

Peptide Sequence - MLPNDLNQDR (amino acids 2069 -2078)

Subclass :

IgG1 kappa

Positive Control :

ELISA- Peptide immunogenWestern Blot- Hela membrane cell extractIF- Hela cells

Myeloma Used :

P3X63Ag8.653

Recommended Growing Conditions :

Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM + 60 ml Fetal Bovine Serum plus 3ml L-Glutamine + 3ml of Penicillin -Streptomycin.

Strain :

Balb/c

Research Area :

DNA Damage and Repair, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage