product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-TIMP2 [3A4]
catalog :
151837
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
350
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry
more info or order :
Ximbio product webpage
product information
Name :
Anti-TIMP2 [3A4]
Catalogue Number :
151837
Applications :
ELISA IHC WB
Antigen/Gene or Protein Targets :
TIMP2 (tissue inhibitor of metalloproteinases 2)
Reactivity :
Human, Mouse, Rat and Zebrafish
Relevance :
Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis. Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
Host :
Mouse
Immunogen :
Ovalbumin-conjugated synthetic peptide; DSGNDIYGNPI
Subclass :
IgG2b
Positive Control :
IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma Western blot: rhTIMP-2, 400 ng per lane
Myeloma Used :
P3X63Ag8.653
Recommended Growing Conditions :
Dulbecco’s media containing L-Glutamine and 20% Fetal Bovine serum (DH20) .
Strain :
Balb/c
Research Area :
Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Protein Degradation
Notes :
(i) no cross-reactivity with TIMP-1 in immunoblot, (ii) staining in antigen-positive wax-imbedded tissues
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com